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  5. Array-Associated Reverse Transcriptase
Core Conceptsaka ART

Array-Associated Reverse Transcriptase

Array-associated reverse transcriptases (ART) are a candidate enzyme system in bacteriophages: a reverse transcriptase, an accessory protein of unknown function, and a long array of repeating non-coding DNA resembling a CRISPR array.

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Anthropic reported in September 2026 that Claude agents flagged the system after searching a DNA database for reverse transcriptases, and early experiments show the array is expressed as short RNAs. Its function is not yet known and the work is a pre-print, so it is a candidate discovery rather than an established gene-editing tool.

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